TY  - JOUR
T1  - DEvelopment of acromegaly after pituitary apoplexy
AU  - Candrina R, Giustina G
Y1  - 1986/12/05
N1  - 10.1001/jama.1986.03380210094033
JO  - JAMA
SP  - 2998
EP  - 3000
VL  - 256
IS  - 21
N2  - THE OCCURRENCE of partial necrosis of a pituitary adenoma is a wellknown phenomenon, originally observed by Bleibtreu1 in a patient with acromegaly. It has been aptly termed pituitary apoplexy2 and has been reported to take place in approximately 10% of affected patients.3,4 Its occurrence in acromegalic patients has been recorded more than 40 times, and clinical signs of acromegaly were always present beforehand.4-8 An apparent spontaneous cure of acromegaly, with remission of acromegalic features after the apoplectic episode, occurs frequently,6,8 but a recurrence of acromegaly, after a long period of clinical inactivity of disease following an episode of pituitary apoplexy, has also been described.7We describe a young woman who presented after the spontaneous occurrence of pituitary apoplexy and had had a previously unsuspected, endocrinologically silent pituitary tumor excised by transsphenoidal approach. Pituitary functions partially recovered, but three years later she experienced the recurrence
SN  - 0098-7484
M3  - doi: 10.1001/jama.1986.03380210094033
UR  - http://dx.doi.org/10.1001/jama.1986.03380210094033
ER  -