TY  - JOUR
T1  - LUpus erythematosus, dna, and sunshine
Y1  - 1969/12/08
N1  - 10.1001/jama.1969.03160360061016
JO  - JAMA
SP  - 1915
EP  - 1915
VL  - 210
IS  - 10
N2  - In 1851 Casenave, in describing lupus erythematosus, mentioned exacerbations of the disease related to cold, heat, and direct action of the air. In the last instance, perhaps he was describing the effect of sunlight on the skin of patients with lupus erythematosus, a relationship that has since become well known. Its importance has been questioned and it has often been explained as an isomorphic (Koebner) phenomenon probably not playing a major etiologic role in the disease. Now, Freeman et al, reporting in the current issue of the Archives of Dermatology,1 describe persistent scaly erythematous skin lesions induced in patients with lupus erythematosus by exposure to monochromatic ultraviolet. These lesions clinically and histologically resembled the patient's naturally occurring skin eruption. The energy used to induce these lesions was in the mid ultraviolet "sunburn" range, within the absorption spectral range for both nucleoproteins and proteins.A possible link between the ultraviolet
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03160360061016
UR  - http://dx.doi.org/10.1001/jama.1969.03160360061016
ER  -