TY  - JOUR
T1  - ATaxia-telangiectasia with gastric adenocarcinoma
AU  - Haerer AF, Jackson JF, Evers CG
Y1  - 1969/12/08
N1  - 10.1001/jama.1969.03160360030006
JO  - JAMA
SP  - 1884
EP  - 1887
VL  - 210
IS  - 10
N2  - This communication concerns a large Negro sibship of which five of 12 members had ataxia-telangiectasia. Two affected sisters also had mucinous adenocarcinoma of the stomach in the second decade of life. More detailed studies in one member revealed decreased IgA levels, decreased lymphoblastic transformation index, chromosomal abnormalities, and abnormal thymic and lymphoid tissues, in addition to the typical clinical features of this syndrome. The accepted predisposition to development of lymphoid neoplasms in ataxia-telangiectasia must be extended to include other malignant neoplasms, in view of the occurrence of histologically similar gastric adenocarcinomas in two affected siblings.
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03160360030006
UR  - http://dx.doi.org/10.1001/jama.1969.03160360030006
ER  -