TY - JOUR T1 - EFfect of cyproheptadine on appetite and weight gain in adults AU - Noble RE Y1 - 1969/09/29 N1 - 10.1001/jama.1969.03160260058019 JO - JAMA SP - 2054 EP - 2055 VL - 209 IS - 13 N2 - Cyproheptadine (Periactin) hydrochloride, a histamine and serotonin antagonist, was compared with placebo for effectiveness in producing appetite stimulation and weight gain in healthy, underweight, adults. Increase in appetite and weight was significantly greater statistically in those who received cyproheptadine. Drowsiness was a common transient side effect of cyproheptadine. There were no significant alterations in laboratory values following cyproheptadine administration. SN - 0098-7484 M3 - doi: 10.1001/jama.1969.03160260058019 UR - http://dx.doi.org/10.1001/jama.1969.03160260058019 ER -