TY  - JOUR
T1  - NEurocutaneous melanosis and melanomas in children
Y1  - 1969/09/22
N1  - 10.1001/jama.1969.03160250054013
JO  - JAMA
SP  - 1898
EP  - 1899
VL  - 209
IS  - 12
N2  - The embryonic development of the central nervous system from the primitive ectodermal layer is occasionally associated with abnormalities of both the skin and the central nervous system. Variants of these combinations form the phakomatoses of which tuberous sclerosis (Bourneville's disease), von Recklinghausen's disease, and Sturge-Weber disease are the most widely recognized. Recently a less commonly observed phakomatosis containing giant pigmented nevi (bathing-trunk nevi) and cerebral melanocytosis or melanomatosis has been more frequently appreciated. Reed et al1 cited 20 well-examined cases including one of his own, in which conspicuous melanotic infiltrates of the nervous system were seen. Such changes were particularly conspicuous in those cases in which the giant nevi involved the neck and scalp. Twelve of these cases had bathing-trunk nevi, and nearly all demonstrated some neurologic difficulty.In a recent issue of the Archives of Pathology, a report by Slaughter et al2 describes four additional cases of
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03160250054013
UR  - http://dx.doi.org/10.1001/jama.1969.03160250054013
ER  -