TY  - JOUR
T1  - BActerial shock
AU  - Barnett JA, Sanford JP
Y1  - 1969/09/08
N1  - 10.1001/jama.1969.03160230048012
JO  - JAMA
SP  - 1514
EP  - 1517
VL  - 209
IS  - 10
N2  - As a cause of clinical shock, sepsis is surpassed in frequency only by hemorrhage and myocardial infarction. The most common offending organisms are gram-negative bacteria, although septic shock may occasionally occur after infection with fungi, rickettsiae, viruses, and gram-positive bacteria. Infections with gram-negative bacilli are increasing in frequency and at present constitute the most commonly encountered life-threatening infections in patients in general hospitals. The mortality in large accumulated series of patients with gram-negative bacteremia approximates 40%. In patients in whom shock develops as a consequence of the bacteremia, the death rate ranges from 50% to 80%.Mechanism 
    The pathophysiology of bacterial shock is incompletely understood. It is believed, however, that endotoxin, a complex lipopolysaccharide common to the cell wall of all gram-negative bacteria, plays a major role in initiating the hemodynamic events.1 Most experimental evidence supports the view that endotoxin effects a redistribution of blood within the vascular bed
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03160230048012
UR  - http://dx.doi.org/10.1001/jama.1969.03160230048012
ER  -