TY  - JOUR
T1  - THerapeutic uses of digoxin antibody
Y1  - 1969/09/01
N1  - 10.1001/jama.1969.03160220049015
JO  - JAMA
SP  - 1359
EP  - 1360
VL  - 209
IS  - 9
N2  - "Man bites dog" is proverbially more newsworthy than "dog bites man." News about a new drug capable of suppressing antibody formation or activity would generate little excitement; drug-induced immuno-suppression has been with us for some time. Much more startling is the news that an antibody can inhibit the activity of a drug. Such a phenomenon is the recently reported immunologic reversal of digoxin toxicity. Schmidt and Butler1 succeeded in producing specific antibodies in rabbits and dogs immunized with digoxin-human serum albumin conjugates. These antibodies proved capable of reversing severe, established, digoxin toxicity. Twelve unanesthetized dogs were given toxic doses of digoxin, which induced atrial ventricular block, ventricular premature contractions, and ventricular tachycardia. Five of these dogs received no treatment, two were given normal canine plasma, and the remaining five were treated with rabbit serum containing digoxin-specific antibodies. Only the last group survived. The animals reverted to sinus rhythm within
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03160220049015
UR  - http://dx.doi.org/10.1001/jama.1969.03160220049015
ER  -