TY  - JOUR
T1  - EFfect of sodium depletion on renin activity of renal venous plasma in renovascular hypertension
AU  - Vermillion SE, Sheps SG, Strong CG, Harrison EG, Jr., Hunt JC
Y1  - 1969/06/23
N1  - 10.1001/jama.1969.03160120026006
JO  - JAMA
SP  - 2302
EP  - 2306
VL  - 208
IS  - 12
N2  - In a patient with renovascular hypertension, renal venous renin-activity determinations were carried out during normal sodium intake, after sodium depletion, and after sodium repletion. When the patient was eating a normal sodium diet, renal venous renin-activity levels failed to lateralize, a finding consistent with the results of isotope renography and two separated renal function studies. However, renal venous renin-activity ratios lateralized (ratios greater than 2:1) to the affected side when the patient's severe sodium depletion lasted for three days. From this finding, it was correctly predicted that relief of hypertension would follow nephrectomy for complete occlusion of a branch artery secondary to fibromuscular dysplasia. Acute sodium depletion increases the diagnostic sensitivity of renal venous renin-activity testing in the determination of functional significance of renovascular lesions in hypertensive patients.
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03160120026006
UR  - http://dx.doi.org/10.1001/jama.1969.03160120026006
ER  -