TY - JOUR T1 - OVarian dysfunction associated with an anticonvulsant drug AU - Cash R, Petrini MA, Brough A Y1 - 1969/05/19 N1 - 10.1001/jama.1969.03160070027006 JO - JAMA SP - 1149 EP - 1152 VL - 208 IS - 7 N2 - Multiple endocrinopathies associated with the longterm administration of an anticonvulsant drug, aminoglutethimide (Elipten), were observed in a 19-year-old girl. The patient demonstrated minimal thyroid dysfunction with virilization as the major clinical manifestation of drug toxicity. Virilization was attributed to a disturbance in ovarian steroidogenesis. Evaluation of ovarian function should be undertaken in all women who continue to receive the drug for prolonged periods. SN - 0098-7484 M3 - doi: 10.1001/jama.1969.03160070027006 UR - http://dx.doi.org/10.1001/jama.1969.03160070027006 ER -