TY  - JOUR
T1  - CAncer chemotherapy aimed at potential cell regulators
AU  - Knock FE, Galt RM, Oester YT, Renaud OV
Y1  - 1969/04/21
N1  - 10.1001/jama.1969.03160030108022
JO  - JAMA
SP  - 534
EP  - 535
VL  - 208
IS  - 3
N2  - To the Editor:— 
    Marked toxic reactions to wound healing and marrow have plagued clinical cancer chemotherapy with drugs like the nitrogen mustards and fluorouracil attacking nucleic acids or depressing their synthesis. From recent data, sulfhydryl or SH groups on protein appear to play essential roles in regulatory processes from cell membranes to chromosomes.1-3 Nature herself may control cell division by regulating SH groups through use of the SH inhibitor retine.3 Clinically, selected SH inhibitors aimed at potential cell regulators have regressed a variety of human cancers with minimal injury to hematologic status or even improvement in some patients, and without injury to normal wound healing.1,2-4 Administration of the SH inhibitors is usually started 24 to 48 hours after major cancer surgery, such as radical mastectomy, radical hysterectomy, bowel resection, or pelvic exenteration.4Two potent SH inhibitors of markedly different chemical design, oxophenarsine hydrochloride and iodoacetate, are now
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03160030108022
UR  - http://dx.doi.org/10.1001/jama.1969.03160030108022
ER  -