TY  - JOUR
T1  - MEdical news
Y1  - 1969/03/24
N1  - 10.1001/jama.1969.03150250027003
JO  - JAMA
SP  - 2197
EP  - 2210
VL  - 207
IS  - 12
N2  - Liver Failure After Repeated Use Rekindles Halothane Safety Debate 
    A survey of patients with fulminant hepatic failure indicates that a number of them had undergone multiple exposures to halothane anesthesia prior to the onset of symptoms.A report detailing the clinical course in 13 of these patients and suggesting a possible association with multiple halothane exposure was made to the recent meeting of the International Anesthesia Research Society.The report by Charles Trey, MB, ChB, research associate, Thorndike Memorial Laboratory, Boston City Hospital, prompted a vigorous round in the continuing debate over the hepatotoxic potential of halothane.On the one hand, Dr. Trey feels evidence is sufficient to consider unexplained fever following minor surgery using halothane as a relative contraindication to the reuse of halothane. Postoperative hepatocellular jaundice should be regarded as an absolute contraindication to further exposure to halothane.Dr. Trey recommended these precautions as the only feasible
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03150250027003
UR  - http://dx.doi.org/10.1001/jama.1969.03150250027003
ER  -