TY  - JOUR
T1  - CYtogenetic diagnosis of down's syndrome in utero
AU  - Valenti C, Schutta EJ, Kehaty T
Y1  - 1969/02/24
N1  - 10.1001/jama.1969.03150210097018
JO  - JAMA
SP  - 1513
EP  - 1515
VL  - 207
IS  - 8
N2  - Fetal cells, obtained by amniocentesis from a balanced carrier of D/G chromosome translocation during the 18th week of pregnancy, were analyzed after 22 days of cultivation in vitro. The karyotypes showed a modal chromosome number of 46, with the D/G fusion chromosome characteristic of Down's syndrome. Pregnancy was interrupted by intra-amniotic instillation of hypertonic saline solution. A 700-gm, macerated, male fetus was delivered and showed dermatoglyphic and anatomic changes compatible with the diagnosis made prenatally.
SN  - 0098-7484
M3  - doi: 10.1001/jama.1969.03150210097018
UR  - http://dx.doi.org/10.1001/jama.1969.03150210097018
ER  -