TY  - JOUR
T1  - FIbrinolysis in urologic patients
AU  - Lombardo LJ, Jr.
Y1  - 1959/04/11
N1  - 10.1001/jama.1959.03000320020005
JO  - Journal of the American Medical Association
SP  - 1718
EP  - 1722
VL  - 169
IS  - 15
N2  - Severe hemorrhages after prostatic surgery may be due to a fibrin-dissolving protease found in normal prostatic tissue. The intravascular release of enzyme activators from the prostate may also explain the chronic fibrinolysis that occurs in metastatic carcinoma of the prostate. Experiments in vitro showed that the activity of these enzymes can be opposed by inhibitors. The effectiveness of two preparations of toluidine blue as inhibitors was convincingly shown by observations of plasma fibrinogen levels in 3 groups of 30 patients undergoing prostatectomy. One group received an oral preparation, the second, a parenteral preparation. The third group served for comparison. Liquefaction of extravasated blood in the prostatic fossa was found to be a characteristic phenomenon, but the question is raised whether this may be an essential part of some reparative process. Two case histories illustrate the occurrence and treatment of hemorrhage after prostatectomy.
SN  - 0002-9955
M3  - doi: 10.1001/jama.1959.03000320020005
UR  - http://dx.doi.org/10.1001/jama.1959.03000320020005
ER  -