TY - JOUR T1 - THe nephrotic syndrome AU - Kark RM, Pirani CL, Pollak V Y1 - 1959/04/04 N1 - 10.1001/jama.1959.03000310109025 JO - Journal of the American Medical Association SP - 1657 EP - 1657 VL - 169 IS - 14 N2 - To the Editor:—  The editorial on the nephrotic syndrome in The Journal ( 169:846 [Feb. 21] 1959) disturbs us since we are sure it will confuse many readers. It quotes two references by ourselves and our co-workers which deal with the nephrotic syndrome. The other reference is a paper by Hodges (J. M. Soc. New Jersey54:11 [Jan.] 1957) which deals with the lower nephron syndrome—so-called lower nephron nephrosis or acute tubular necrosis. Since there is no clinical and pathological similarity between these two conditions, and treatment is completely different, the editorial is confusing and misleading. In discussing the nephrotic syndrome, the editorial states that "pathologically the characteristic lesion is necrosis of the tubules." This lesion is seen in lower nephron nephrosis but not in the nephrotic syndrome. There are no characteristic histological lesions in the kidneys of patients with nephrotic syndrome. This condition has many causes and many SN - 0002-9955 M3 - doi: 10.1001/jama.1959.03000310109025 UR - http://dx.doi.org/10.1001/jama.1959.03000310109025 ER -