TY  - JOUR
T1  - HYperheparinemia, white emboli and leukergy
AU  - Fleck L
Y1  - 1949/02/19
N1  - 10.1001/jama.1949.02900250046023
JO  - Journal of the American Medical Association
SP  - 542
EP  - 542
VL  - 139
IS  - 8
N2  - To the Editor:— 
    With reference to Alfred L. Copley's article, "Hemorrhagic Diathesis in Hiroshima," The Journal (137: 145 [May 8] 1948), I should like to make the following suggestions:In a number of experiments conducted in our laboratories at the beginning of 1948 I had definite evidence which convinced me that heparin in vitro and in vivo (even in doses smaller than needed for the prevention of blood coagulation) causes agglutination of thrombocytes—thus contradicting the opinion hold by most writers (Jorpes, Solandt and Best, Boyd, Whitby and Britton and others). I am glad that the findings of Copley and his co-workers are the same. Independently of the agglutination of thrombocytes, however, heparin causes also a clumping of the white blood cells, mainly granulocytes. It can be proved that this agglutination of leukocytes is independent of the presence of platelets, because it takes place also in the blood of an
SN  - 0002-9955
M3  - doi: 10.1001/jama.1949.02900250046023
UR  - http://dx.doi.org/10.1001/jama.1949.02900250046023
ER  -