TY  - JOUR
T1  - ISolation of tail of pancreas in a diabetic child
AU  - DE TAKÁTS G, WILDER RM
Y1  - 1929/08/24
N1  - 10.1001/jama.1929.02710080032012
JO  - Journal of the American Medical Association
SP  - 606
EP  - 610
VL  - 93
IS  - 8
N2  - One of us (de Takáts) is reporting elsewhere experiments on dogs which bring additional evidence of the persistence, hypertrophy and function of the islet tissue in the tail of the pancreas after separation of the tail from the body of the gland.1 This operation does not interfere with the supply of pancreatic juice to the duodenum. Increase in diastase appears in the blood at first, but disappears in two weeks and can no longer be demonstrated, even after stimulation with pilocarpine, after three weeks.2 The islets in the severed tail develop to an unusual size, mitotic figures appearing in many sections. An increased tolerance for sugar has been demonstrated in these dogs with dextrose test meals and by means of intravenous injections of dextrose at timed rates. Furthermore, an injection of epinephrine produces in them a less marked hyperglycemia than normal or a paradox hypoglycemia.This work was
SN  - 0002-9955
M3  - doi: 10.1001/jama.1929.02710080032012
UR  - http://dx.doi.org/10.1001/jama.1929.02710080032012
ER  -