TY  - JOUR
T1  - THe untoward effects of treatment by phenylhydrazine hydrochloride
AU  - GIFFIN HZ, CONNER H
Y1  - 1929/05/04
N1  - 10.1001/jama.1929.02700440013007
JO  - Journal of the American Medical Association
SP  - 1505
EP  - 1507
VL  - 92
IS  - 18
N2  - Phenylhydrazine hydrochloride has come into general use as a therapeutic agent in the treatment of polycythemia vera. It was employed experimentally in animals in 1885 by Hoppe-Seyler.1 Morawitz and Pratt2 in 1908 used it for the purpose of producing experimental anemia in animals, and Eppinger and Kloss3 in 1918 were the first to apply it clinically in cases of polycythemia vera. The reports that have appeared in the literature since that time concerning the treatment of polycythemia vera by means of phenylhydrazine have, in the main, been very favorable. Good results have been reported by Eppinger and Kloss,3 Taschenberg,4 Levi,5 Owen,6 Brown and Giffin,7 Altnow and Carey,8 Stealy9 and Cabot.10 Bryan11 alone called attention to possible serious unfavorable effects of phenylhydrazine. In the early cases an unnecessarily severe anemia was produced and the occurrence of thrombosis was noted. The
SN  - 0002-9955
M3  - doi: 10.1001/jama.1929.02700440013007
UR  - http://dx.doi.org/10.1001/jama.1929.02700440013007
ER  -