TY  - JOUR
T1  - EXcretion of neutral red in the stomach in achylia gastrica
AU  - WINKELSTEIN A, MARCUS JM
Y1  - 1929/04/13
N1  - 10.1001/jama.1929.02700410008003
JO  - Journal of the American Medical Association
SP  - 1238
EP  - 1240
VL  - 92
IS  - 15
N2  - In 1908, Fuld1 discovered that neutral red would appear in a Pavlov pouch after it was placed in the large stomach. Many years later, Finkelstein2 found that it was practically the only dyestuff eliminated in appreciable quantities in the Pavlov pouches of dogs. In 1923, one year later, Glaessner and Wittgenstein3 applied this fact clinically. Finding that this dyestuff was nontoxic and not irritating locally, they injected 4 cc. of a 1 per cent watery solution intramuscularly in forty patients. They found that the appearance time of the neutral red in the stomach paralleled the acidity; i. e., in normal persons it was fifteen minutes; in hyperacidity, from five to eight minutes; in subacidity, from twenty to sixty minutes; and in achylia gastrica, it did not appear. In 1925, being interested in the possibility of improving our studies of gastric function, we4 repeated this work in
SN  - 0002-9955
M3  - doi: 10.1001/jama.1929.02700410008003
UR  - http://dx.doi.org/10.1001/jama.1929.02700410008003
ER  -