TY - JOUR T1 - INtra-abdominal inflammation in relation to diabetic acidosis with leukocytosis AU - SMITH JH Y1 - 1929/01/26 N1 - 10.1001/jama.1929.02700300032008 JO - Journal of the American Medical Association SP - 308 EP - 309 VL - 92 IS - 4 N2 - In severe diabetic acidosis an acute abdominal lesion may be closely simulated, and again such a lesion may actually exist. The diagnostic difficulty is increased by the claim that leukocytosis may occur in acidosis independent of the inflammatory factor. Doubtless every observer has hesitated to accept this conclusion, feeling that the acidosis may have been precipitated by an inflammatory state that was not recognized. This hesitation would be more strongly felt if a fair percentage of patients did, at one time or another, develop recognized and demonstrable abdominal disease, such as acute appendicitis. However, a number of careful observers have reported their conclusion that otherwise uncomplicated diabetic acidosis may be characterized by leukocytosis.1Some of the following abstracts of cases emphasize the importance of a guarded acceptance of acidosis as the cause of abdominal symptoms and leukocytosis, while others suggest the validity of the belief that both abdominal pain SN - 0002-9955 M3 - doi: 10.1001/jama.1929.02700300032008 UR - http://dx.doi.org/10.1001/jama.1929.02700300032008 ER -