TY  - JOUR
T1  - A 60-year-old woman trying to discontinue hormone replacement therapy, 2 years later
AU  - Reynolds EE
Y1  - 2005/04/13
N1  - 10.1001/jama.293.14.1780
JO  - JAMA
SP  - 1780
EP  - 1780
VL  - 293
IS  - 14
N2  - 
In her discussion, which was published after the Women’s Health
Initiative announcement regarding concerning trends in the study2 but
prior to publication of the study,3- 4 Dr
Grady discussed growing concerns about the potentially increased risk of breast
cancer risk and coronary events in users of hormone therapy based on the Heart
and Estrogen/Progestin Replacement Study, other published randomized trials,
and early reports from the Women’s Health Initiative. She suggested
that Mrs W try again to taper her estrogen, but over an extended period of
time. Dr Grady also suggested that Mrs W consider trying a selective serotonin
reuptake inhibitor to help with symptoms. However, she noted that estrogen
remains the most effective therapy for relief of vasomotor symptoms of menopause
and suggested that if Mrs W were unable to taper or discontinue the estrogen,
that Mrs W could continue the estrogen, but for symptom relief rather than
long-term prevention of disease.

SN  - 0098-7484
M3  - doi: 10.1001/jama.293.14.1780
UR  - http://dx.doi.org/10.1001/jama.293.14.1780
ER  -