TY  - JOUR
T1  - HIgh-altitude pulmonary edema
AU  - Hackett P, Rennie D
Y1  - 2002/05/01
N1  - 10.1001/jama.287.17.2275
JO  - JAMA
SP  - 2275
EP  - 2278
VL  - 287
IS  - 17
N2  - 
In 1986, THE JOURNAL published an important advance in the understanding
of HAPE.1 Schoene et al showed that climbers
who had HAPE and underwent bronchoalveolar lavage (BAL) at a camp set up at
4400 m on Denali (Mount McKinley, 6194 m) had lavage fluid with a high concentration
of protein compared with lavage fluid from 3 healthy investigators. In addition,
the presence of complement activation and lipoxygenase metabolites indicated
a degree of inflammation, but the white blood cell differential revealed alveolar
macrophages, not polymorphonuclear leukocytes. The researchers concluded that
"the early events in HAPE involve a change in permeability, without major
activation of inflammatory mechanisms. . . . " In the same issue of THE JOURNAL,
Hackett et al2 showed that the total protein
content of pulmonary edema fluid in a skier who had HAPE and was brought down
to 1285 m was the same as that in the serum.

SN  - 0098-7484
M3  - doi: 10.1001/jama.287.17.2275
UR  - http://dx.doi.org/10.1001/jama.287.17.2275
ER  -