TY  - JOUR
T1  - RIsk of non-hodgkin lymphoma in celiac disease
AU  - Catassi C, Fabiani E, Corrao G, et al
Y1  - 2002/03/20
N1  - 10.1001/jama.287.11.1413
JO  - JAMA
SP  - 1413
EP  - 1419
VL  - 287
IS  - 11
N2  - Context 
                  Celiac disease is one of the most common lifelong disorders. Non-Hodgkin
lymphoma is a possible complication of celiac disease and may lead to a large
portion of lymphoma cases.Objective 
                  To quantify the risk for developing non-Hodgkin lymphoma of any primary
site associated with celiac disease.Design and Setting 
                  Multicenter, case-control study conducted between January 1996 and December
1999 throughout Italy.Patients 
                  Cases were older than 20 years (median, 57; range, 20-92 years) with
non-Hodgkin lymphoma of any primary site and histological type and were recruited
at the time of the diagnosis. Controls were healthy adults (2739 men and 2981
women) from the general population.Main Outcome Measure 
                  Positive test result for class A serum antiendomysial antibody.Results 
                  Celiac disease was diagnosed in 6 (0.92%) of 653 patients with lymphoma.
Of the 6 cases, 3 were of B-cell and 3 were of T-cell origin. Four of 6 cases
had lymphoma primarily located in the gut. In the control group, 24 (0.42%)
had celiac disease. The odds ratio (adjusted for age and sex) for non-Hodgkin
lymphoma of any primary site associated with celiac disease was 3.1 (95% confidence
interval [CI], 1.3-7.6), 16.9 (95% CI, 7.4-38.7) for gut lymphoma, and 19.2
(95% CI, 7.9-46.6) for T-cell lymphoma, respectively. The risk for non-Hodgkin
lymphoma for the overall population, which was adjusted for age and sex, was
0.63% (95% CI, − 0.12% to 1.37%).Conclusion 
                  Celiac disease is associated with an increased risk for non-Hodgkin
lymphoma, especially of T-cell type and primarily localized in the gut. However,
the association does not represent a great enough risk to justify early mass
screening for celiac disease.
SN  - 0098-7484
M3  - doi: 10.1001/jama.287.11.1413
UR  - http://dx.doi.org/10.1001/jama.287.11.1413
ER  -