TY  - JOUR
T1  - HOw do observational studies expand the evidence base for therapy?
AU  - Radford MJ, Foody JM
Y1  - 2001/09/12
N1  - 10.1001/jama.286.10.1228
JO  - JAMA
SP  - 1228
EP  - 1230
VL  - 286
IS  - 10
N2  - 
The impressive advances in cardiovascular therapy during the last several
decades owe a great deal to randomized trials.1
The foundation for 21st-century cardiovascular care has been laid, therapy
by therapy, through the disciplined application of randomized trial methodology
to important scientific insights and therapeutic uncertainties. The random
assignment of patients to receive one care strategy or therapy vs another
has allowed investigators to separate consistent therapeutic efficacy "signals"
from the "noise" of patient variability and physician bias.

SN  - 0098-7484
M3  - doi: 10.1001/jama.286.10.1228
UR  - http://dx.doi.org/10.1001/jama.286.10.1228
ER  -