TY  - JOUR
T1  - BLood progenitors from skin
AU  - Hampton T
Y1  - 2010/12/15
N1  - 10.1001/jama.2010.1802
JO  - JAMA
SP  - 2582
EP  - 2582
VL  - 304
IS  - 23
N2  - 
Investigators from McMaster University, in Hamilton, Ontario, Canada, have converted human fibroblasts directly into blood progenitors for the first time without first reverting them to a stem cell state (Szabo E et al. Nature. doi:10.1038/nature09591 [published online ahead of print November 7, 2010]). Key to the process was the expression of OCT4 transcription factors together with a specific cytokine treatment. This combination was able to coax human dermal fibroblasts directly into progenitors that can give rise to a full range of mature blood cells, including cells of granulocytic, monocytic, megakaryocytic, and erythroid lineages.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.1802
UR  - http://dx.doi.org/10.1001/jama.2010.1802
ER  -