TY  - JOUR
T1  - MUltiple myeloma
AU  - Pluta RM, Lynm C, Glass RM
Y1  - 2010/12/01
N1  - 10.1001/jama.304.21.2430
JO  - JAMA
SP  - 2430
EP  - 2430
VL  - 304
IS  - 21
N2  - 
Multiple myeloma is a cancer of the bone marrow, also known as plasma cell myeloma or Kahler disease, after Dr Otto Kahler who described it in 1889. In multiple myeloma the bone marrow produces a subtype of white blood cells—plasma cells—that under normal conditions are responsible for production of antibodies  (proteins that fight infections). These malignant plasma cells produce a paraprotein (an inactive antibody known also as M protein  or Bence Jones protein ) that adversely affects bone marrow, bones, blood, and the kidneys. Multiple myeloma is a somewhat uncommon disease that accounts for 1.1% of all cancers in white persons and 2% in elderly black persons and affects more men than women. For many years it has been known that multiple myeloma can have either a mild or very aggressive course. The December 1, 2010, issue of JAMA includes an article describing conditions that consistently precede the development of multiple myeloma.

SN  - 0098-7484
M3  - doi: 10.1001/jama.304.21.2430
UR  - http://dx.doi.org/10.1001/jama.304.21.2430
ER  -