TY  - JOUR
T1  - INfectious alzheimer protein
AU  - Hampton T
Y1  - 2010/12/01
N1  - 10.1001/jama.2010.1716
JO  - JAMA
SP  - 2350
EP  - 2350
VL  - 304
IS  - 21
N2  - 
Intraperitoneal administration of prion-rich material efficiently transmits prion disease. To test whether intraperitoneal inoculation of β-amyloid proteins might similarly trigger β-amyloid misfolding and deposition in the brain, the investigators gave 2 intraperitoneal injections of β-amyloid–laden brain extract from aged mice with Alzheimer-like disease to 6 young mice. After a 7-months, significant cerebral β-amyloid misfolding and deposition occurred in all inoculated mice compared with untreated controls.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.1716
UR  - http://dx.doi.org/10.1001/jama.2010.1716
ER  -