TY  - JOUR
T1  - AUtoimmunity and arthritis
AU  - Friedrich MJ
Y1  - 2010/11/03
N1  - 10.1001/jama.2010.1517
JO  - JAMA
SP  - 1888
EP  - 1888
VL  - 304
IS  - 17
N2  - 
Researchers from the University of Rochester in New York and collaborators from across the United States and China discovered that the protein subunit G alpha q (Gaq) is part of a signaling pathway that determines the fate of autoreactive B cells and prevents them from building up and mistakenly attacking the body's own tissues. They showed that in mice genetically modified to lack Gaq, these harmful B cells survive and cause rapid development of arthritis and other manifestations of autoimmune disease.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.1517
UR  - http://dx.doi.org/10.1001/jama.2010.1517
ER  -