TY  - JOUR
T1  - KEtamine’s success
AU  - Hampton T
Y1  - 2010/10/06
N1  - 10.1001/jama.2010.1368
JO  - JAMA
SP  - 1432
EP  - 1432
VL  - 304
IS  - 13
N2  - 
Experiments in rats revealed that ketamine rapidly activates the brain's rapamycin, or mTOR, signaling pathway, which controls protein synthesis required for new synaptic connections between neurons. Specifically, ketamine's actions on this pathway restored connections between the rats’ prefrontal cortex neurons that had been damaged by chronic stress. The investigators could reverse these effects by simply blocking the mTOR signaling pathway.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.1368
UR  - http://dx.doi.org/10.1001/jama.2010.1368
ER  -