TY  - JOUR
T1  - HIgh-dose oral vitamin d supplementation and risk of falls in older women
AU  - Malgarini R, Pimpinella G
Y1  - 2010/08/25
N1  - 10.1001/jama.2010.1168
JO  - JAMA
SP  - 854
EP  - 857
VL  - 304
IS  - 8
N2  - 
Experimental data2 demonstrate that vitamin D3 in vitro promotes the differentiation of osteoclasts from monocyte macrophage stem cell precursors and at high doses increases in vivo osteoclastic bone resorption. This latter effect depends on vitamin D3 increasing the production in osteoblasts of RANKL (receptor activator for nuclear factor-κ B ligand), a key factor necessary for osteoclast differentiation and activation. This casts further doubt on the safety of high doses of vitamin D in patients at high risk of fractures and should be taken into account in the design of future studies.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.1168
UR  - http://dx.doi.org/10.1001/jama.2010.1168
ER  -