TY  - JOUR
T1  - HIgh-dose oral vitamin d supplementation and risk of falls in older women
AU  - Mak JS
Y1  - 2010/08/25
N1  - 10.1001/jama.2010.1165
JO  - JAMA
SP  - 854
EP  - 857
VL  - 304
IS  - 8
N2  - 
To the Editor: In their randomized controlled trial comparing annual high-dose oral vitamin D in older community-dwelling women, Dr Sanders and colleagues1 found a significantly greater relative risk of falls in the vitamin D group vs placebo group during the first 3 months of treatment than in the following 9 months. They also found a statistically nonsignificant greater risk of fractures in the first 3 months. It is not clear whether these adverse effects mainly occurred in the first month or between months 1 and 3, as may be expected with the precipitous drop in 25-hydroxycholecalciferol levels from months 1 to 3.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.1165
UR  - http://dx.doi.org/10.1001/jama.2010.1165
ER  -