TY  - JOUR
T1  - DIagnostic testing for celiac disease—reply
AU  - van der Windt D, Kneepkens F, van der Horst H
Y1  - 2010/08/11
N1  - 10.1001/jama.2010.1110
JO  - JAMA
SP  - 639
EP  - 640
VL  - 304
IS  - 6
N2  - 
In Reply: Drs Plebani and Basso rightly point out that IgA-tTG tests using human antigens have been shown to have better diagnostic performance compared with older tests using guinea pig tissue. We presented information on test characteristics but did not carry out subgroup analyses to demonstrate their effects on diagnostic performance. The number of studies using guinea pig antigens is too small to compute pooled estimates, but bivariate analyses limited to studies using human tissue for IgA-tTG tests (n = 4) show a pooled estimate of 0.94 (95% confidence interval, 0.74-0.99) for sensitivity and 0.98 (95% confidence interval, 0.96-0.99) for specificity, a slightly better sensitivity and similar specificity compared with the overall pooled estimates presented in our review.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.1110
UR  - http://dx.doi.org/10.1001/jama.2010.1110
ER  -