TY - JOUR T1 - ALs and neurotoxins AU - Stephenson J Y1 - 2010/06/16 N1 - 10.1001/jama.2010.798 JO - JAMA SP - 2346 EP - 2346 VL - 303 IS - 23 N2 - Previously, researchers proposed that a neurotoxin called β-methylamino-L-alanine (BMAA), produced by cyanobacteria in the roots of certain plants, accumulated in the food chain and caused the very high incidence of an illness similar to amyotrophic lateral sclerosis (ALS) that occurred in the Chamorro people in Guam in the late 1940s and early 1950s. Studies in animals and cultured cells, as well as studies that found BMAA in brain tissue of some patients with Alzheimer disease or ALS, also implicated BMAA as a potential factor in neurodegenerative disease. SN - 0098-7484 M3 - doi: 10.1001/jama.2010.798 UR - http://dx.doi.org/10.1001/jama.2010.798 ER -