TY  - JOUR
T1  - INfluenza vaccination of children and infection rates in the community
AU  - Small PA, Morris J
Y1  - 2010/06/16
N1  - 10.1001/jama.2010.779
JO  - JAMA
SP  - 2355
EP  - 2356
VL  - 303
IS  - 23
N2  - 
To the Editor: The randomized study by Dr Loeb and colleagues1 of communities receiving either inactivated influenza vaccine or hepatitis A vaccine supports school-based influenza immunization and adds credence to a nationwide Japanese study that concluded that 1 life was saved for every 420 children immunized against influenza.2 The study by Loeb et al showed protection of community members against clinical illness, confirmed by real-time reverse transcriptase–polymerase chain reaction assay, but failed to show protection against infection as determined by hemagglutination inhibition titers. The authors speculated that “[o]ne possible explanation for the lack of significant differences in serologic outcomes is that the influenza vaccination may have attenuated infection that . . . rendered it subclinical but without preventing infection.”

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.779
UR  - http://dx.doi.org/10.1001/jama.2010.779
ER  -