TY  - JOUR
T1  - PArkinson disease insights
AU  - Hampton T
Y1  - 2010/06/02
N1  - 10.1001/jama.2010.685
JO  - JAMA
SP  - 2129
EP  - 2129
VL  - 303
IS  - 21
N2  - 
One gene encodes parkin, which adds ubiquitin molecules to other proteins to trigger their degradation; the second gene, PINK1 (PTEN-induced putative kinase 1), is involved with mitochondrial maintenance. Problems with ubiquitination and mitochondrial integrity are key factors in the pathogenesis of Parkinson disease.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.685
UR  - http://dx.doi.org/10.1001/jama.2010.685
ER  -