TY  - JOUR
T1  - ASsessment of atherosclerosis in egyptian mummies—reply
AU  - Thomas GS
Y1  - 2010/03/24
N1  - 10.1001/jama.2010.327
JO  - JAMA
SP  - 1149
EP  - 1150
VL  - 303
IS  - 12
N2  - 
In Reply: Drs Charlier and Huynh propose that mediasclerosis is a unique disease, manifest as calcification of the tunica medica, a disease completely different from atherosclerosis, which they presumably would define exclusively as a disease of the intima. We believe that atherosclerosis is a multifaceted, systemic disease that encompasses both of these histologic features. The earliest pathologic manifestations of atherosclerosis include intimal thickening and fatty streaks, but complex changes occur as the disease progresses, with structural remodeling of the vessel, cellular infiltrates, lipid accumulation, thrombosis, fibrosis, and calcification involving the media as well as the adventitia.1

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.327
UR  - http://dx.doi.org/10.1001/jama.2010.327
ER  -