TY  - JOUR
T1  - PRone positioning in patients with acute respiratory distress syndrome
AU  - Russell JA
Y1  - 2010/03/03
N1  - 10.1001/jama.2010.183
JO  - JAMA
SP  - 832
EP  - 833
VL  - 303
IS  - 9
N2  - 
Shock and hemodynamic instability make prone positioning more difficult and potentially less safe. Furthermore, hemodynamic alterations and vasoactive agents (such as α- and β-adrenergic agents used clinically, including norepinephrine, dopamine, and dobutamine) can change perfusion distribution in the lung, alter gas exchange, and worsen oxygenation. Thus, over time a patient could move out of a state of being ineligible for the trial, and could also move from a classification of moderate to severe hypoxemia, with no change in the underlying ARDS pathology.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2010.183
UR  - http://dx.doi.org/10.1001/jama.2010.183
ER  -