TY  - JOUR
T1  - TYphoid fever in the united states and antibiotic choice—reply
AU  - Lynch MF, Mintz ED
Y1  - 2010/01/06
N1  - 10.1001/jama.2009.1936
JO  - JAMA
SP  - 34
EP  - 35
VL  - 303
IS  - 1
N2  - 
For patients with suspected typhoid fever in whom the probability of infection with a decreased ciprofloxacin susceptibility strain is low, fluoroquinolones may be started empirically and therapy continued if antimicrobial susceptibility testing confirms infection with a susceptible S Typhi strain. However, for typhoid fever patients in whom the probability of infection with a decreased ciprofloxacin susceptibility strain is high, such as those returning from South Asia or those in whom infection with a decreased ciprofloxacin susceptibility strain has been documented by susceptibility testing, an alternative therapy is warranted. Third-generation cephalosporins have been used in this situation, most commonly intravenous ceftriaxone. The oral third-generation cephalosporin cefixime has been associated with a high rate of clinical failures.2 Recent studies have shown that azithromycin can also be used effectively for uncomplicated typhoid fever due to infection with decreased ciprofloxacin susceptibility S Typhi strains in endemic areas.3

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.1936
UR  - http://dx.doi.org/10.1001/jama.2009.1936
ER  -