TY  - JOUR
T1  - BIomarkers for prediction of cardiovascular events
AU  - Rosenstein RS, Parra D
Y1  - 2009/11/18
N1  - 10.1001/jama.2009.1637
JO  - JAMA
SP  - 2089
EP  - 2090
VL  - 302
IS  - 19
N2  - 
When assessing the value of a biomarker within a well-calibrated system, the C statistic of the receiver operating characteristic curve is used to evaluate its potential incremental benefit over other risk factors or panels. In the study by Melander et al, as well as in past studies,2 the results of this approach have been disappointing because of the very modest improvement compared with most traditional risk markers. The more correlated a novel marker is with traditional risk factors, the less its addition may improve discrimination.3

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.1637
UR  - http://dx.doi.org/10.1001/jama.2009.1637
ER  -