TY  - JOUR
T1  - GEne-environment interactions and depression
AU  - Koenen KC, Galea S
Y1  - 2009/11/04
N1  - 10.1001/jama.2009.1575
JO  - JAMA
SP  - 1859
EP  - 1862
VL  - 302
IS  - 17
N2  - 
To the Editor: In their meta-analysis, Dr Risch and colleagues1 concluded that the study of gene-environment interaction in mental disorders should await the identification of “robust marginal gene associations.” We believe that this conclusion extends well beyond the data, and an alternate explanation of their findings suggests other courses of action. The absence of replicable findings across studies that assessed both direct genotype-depression associations and gene-environment interactions may be explained by mismeasurement and undermeasurement of relevant environmental contexts.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.1575
UR  - http://dx.doi.org/10.1001/jama.2009.1575
ER  -