TY - JOUR T1 - RHeumatoid arthritis AU - Quinet RJ Y1 - 2009/11/04 N1 - 10.1001/jama.2009.1597 JO - JAMA SP - 1909 EP - 1914 VL - 302 IS - 17 N2 - One example is the excellent chapter by Zink explaining the details of the various European Biologics Registries, which is contrasted with the chapter by Kremer on the US approach to registries and databases. These chapters can serve as references to help interpret future clinical data forthcoming from these registries. Such registry data are critical to advancing knowledge regarding long-term complications of biologic therapies, particularly malignancies and infections. The section on epidemiology provides an excellent, readable chapter on the latest genetic studies, placing them in historical perspective and, for example, relating new genetic detail regarding the MHC-region HLA- DRĪ²1, its interaction with environmental factors (eg, tobacco), and induction of anti-citrullinated protein antibody formation. SN - 0098-7484 M3 - doi: 10.1001/jama.2009.1597 UR - http://dx.doi.org/10.1001/jama.2009.1597 ER -