TY - JOUR T1 - RAdiation dose-reduction program for cardiac computed tomography angiography—reply AU - Raff GL, Chinnaiyan KM, Abidov A Y1 - 2009/10/28 N1 - 10.1001/jama.2009.1513 JO - JAMA SP - 1753 EP - 1753 VL - 302 IS - 16 N2 - Their suggestions of potential causes of increased numbers of poor or nondiagnostic quality scans are very reasonable. There is another potential cause that we did not quantify but might have been operative. The proportion of scans done at lower tube voltage (100 kVp) significantly increased during the course of our study (from 13% to 43%; P < .001). This had a beneficial effect on radiation dose, but due to the absorption spectrum of iodine would tend to increase the efficiency of absorption of photons at the lower voltage. The result is CT angiograms with a higher mean contrast level than scans done at 120 kVp. This requires adjustment of the window level and window width of the display monitor from the customary settings for 120 kVp. If this is not done, calcium deposits would tend to appear larger and other image distortions occur. Display adjustment was not taught as part of our best-practice guidelines and in retrospect it should have been. We have subsequently added this to the program and the current nondiagnostic scan rate is approximately 5%. SN - 0098-7484 M3 - doi: 10.1001/jama.2009.1513 UR - http://dx.doi.org/10.1001/jama.2009.1513 ER -