TY  - JOUR
T1  - COrticosteroid therapy for severe sepsis and septic shock—reply
AU  - Annane D
Y1  - 2009/10/21
N1  - 10.1001/jama.2009.1482
JO  - JAMA
SP  - 1643
EP  - 1645
VL  - 302
IS  - 15
N2  - 
The potential sources of an asymmetrical funnel plot include selection biases, poor methodological quality of smaller studies, true heterogeneity, artifacts, or chance.1 Visual inspection of the funnel plot suggests a small-study effect (ie, among small studies the positive ones are more likely to be published). Nevertheless, our thorough search strategy and the need to enroll studies in public clinical trial registries may have decreased the risk of missing any randomized control trial. As discussed in the review, all studies on low-dose corticosteroids had acceptable methodological quality.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.1482
UR  - http://dx.doi.org/10.1001/jama.2009.1482
ER  -