TY  - JOUR
T1  - SCientists probe method to prevent inherited mitochondrial gene diseases
AU  - Kuehn BM
Y1  - 2009/10/07
N1  - 10.1001/jama.2009.1401
JO  - JAMA
SP  - 1409
EP  - 1409
VL  - 302
IS  - 13
N2  - 
Mutations in mitochondrial DNA occur at a much higher rate than mutations in nuclear DNA and such mutations may frequently be inherited because offspring obtain their mitochondrial DNA almost exclusively from their mother. Other mutated mitochondrial genes may not be inherited but rather emerge during an individual's lifetime. More than 1500 mutations in mitochondrial DNA are associated with serious disease in humans, including myopathies, neurodegenerative disorders, diabetes, cancer, and infertility. There are no cures for such disorders, only treatments that slow the progression of disease, noted Masahito Tachibana, MD, PhD, the first author of the report, in a press conference.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.1401
UR  - http://dx.doi.org/10.1001/jama.2009.1401
ER  -