TY  - JOUR
T1  - ACid-suppressive medication and hospital-acquired pneumonia
AU  - Wise MP, Saayman AG, Frost PJ
Y1  - 2009/10/07
N1  - 10.1001/jama.2009.1415
JO  - JAMA
SP  - 1415
EP  - 1417
VL  - 302
IS  - 13
N2  - 
To the Editor: Acid suppression therapy is associated with an increased risk of community-acquired pneumonia, and Dr Herzig and colleagues1 reported that these drugs also increase the odds of HAP by 30%. Unlike community-acquired pneumonia, this association was only apparent with proton-pump inhibitors, although it was acknowledged that the study might have been underpowered to detect a smaller effect with histamine2 receptor antagonists. Two mechanisms were suggested for the increase in pneumonia: gastric overgrowth and aspiration of bacteria, and impaired leukocyte function.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.1415
UR  - http://dx.doi.org/10.1001/jama.2009.1415
ER  -