TY  - JOUR
T1  - ADverse outcomes associated with use of proton pump inhibitors and clopidogrel
AU  - Hayes S
Y1  - 2009/07/01
N1  - 10.1001/jama.2009.899
JO  - JAMA
SP  - 29
EP  - 31
VL  - 302
IS  - 1
N2  - 
One major risk not reported in the baseline characteristics or identified in the article is tobacco use status. It is estimated that 11% of total global cardiac deaths are related to cigarette smoking.2 A significant difference in smoking rates between the cohorts could explain the observed difference in outcomes. Additionally, those individuals who smoke might be more likely to have a PPI prescribed to counter risk factors for peptic ulcer disease in users of clopidogrel and aspirin.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.899
UR  - http://dx.doi.org/10.1001/jama.2009.899
ER  -