TY  - JOUR
T1  - OLd disease, innovative response
AU  - Shah SS, Davis MM
Y1  - 2009/06/03
N1  - 10.1001/jama.2009.802
JO  - JAMA
SP  - 2260
EP  - 2261
VL  - 301
IS  - 21
N2  - 

			Disease caused by Bordetella pertussis was once a major cause of morbidity and mortality among infants and young children in industrialized countries.1 Prior to widespread vaccination of infants and toddlers, there were approximately 250 000 cases of pertussis each year in the United States among all age groups. Serious complications such as bronchopneumonia, encephalopathy, and death complicated the course of one-quarter of affected infants younger than 6 months of age.2 In the early 20th century, pertussis killed more than 5 of every 1000 children born in the United States, making this disease an important early target for immunization efforts.1

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.802
UR  - http://dx.doi.org/10.1001/jama.2009.802
ER  -