TY  - JOUR
T1  - BRain tumor clue
AU  - Stephenson J
Y1  - 2009/05/20
N1  - 10.1001/jama.2009.690
JO  - JAMA
SP  - 1977
EP  - 1977
VL  - 301
IS  - 19
N2  - 
The researchers found that IDH1 mutations in glioma tumor cells resulted in reduced levels of α-ketoglutarate (α-KG), which regulates the level of a substance that facilitates angiogenesis and tumor growth when oxygen is low. Adding a modified form of α-KG to glioma cells grown in culture reverses this effect.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.690
UR  - http://dx.doi.org/10.1001/jama.2009.690
ER  -