TY  - JOUR
T1  - CArbimazole treatment in smokers vs nonsmokers with graves disease—reply
AU  - Nyirenda MJ, Beckett GJ, Toft AD
Y1  - 2009/05/20
N1  - 10.1001/jama.2009.557
JO  - JAMA
SP  - 1988
EP  - 1989
VL  - 301
IS  - 19
N2  - 
However, these relationships have not been adequately studied and are likely to be more complex. In particular, it is unclear whether the association between Graves disease and circulating soluble IL-2 receptor concentration reflects the underlying autoimmune activity or, as some studies have suggested, is mediated by the hyperthyroidism. In the latter case, hyperthyroidism of any cause would elevate soluble IL-2 receptor concentration while hypothyroidism would have the opposite effect.1- 3 We agree that further research is needed to fully address these unanswered questions.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.557
UR  - http://dx.doi.org/10.1001/jama.2009.557
ER  -