TY  - JOUR
T1  - EScitalopram treatment of generalized anxiety disorder in older adults—reply
AU  - Lenze EJ
Y1  - 2009/05/20
N1  - 10.1001/jama.2009.652
JO  - JAMA
SP  - 1987
EP  - 1988
VL  - 301
IS  - 19
N2  - 
In Reply: The comments by Ms Schwan and Dr Hallberg highlight measurement and analytic issues in anxiety treatment research. In the study, escitalopram was superior to placebo in cumulative response for GAD in older adults. This primary outcome analysis used the Clinical Global Impression-Improvement scale. Our use of this scale was based on its global assessment of clinical response using all available clinical data, including rating scale data, the patient's report, and the rater's observations. It has clear cut points for a binary outcome such as response, and it had adequate interrater reliability in this study.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.652
UR  - http://dx.doi.org/10.1001/jama.2009.652
ER  -