TY - JOUR T1 - SMallpox AU - Hildreth CJ, Burke AE, Glass RM Y1 - 2009/03/11 N1 - 10.1001/jama.301.10.1086 JO - JAMA SP - 1086 EP - 1086 VL - 301 IS - 10 N2 - Smallpox is a viral infection caused by the Variola virus (an Orthopoxvirus) that can affect people of all ages. Smallpox is contagious and has a 30% fatality rate. The infection manifests with a fever, which precedes the development of a progressive rash that occurs all over the body starting in the mouth and on the face. The rash appears as firm, fluid-filled, and singularly dimpled bumps that eventually become crusty and then form scabs. The rash can persist for several weeks and leaves pitted scars when the scabs fall off. There is no known treatment for smallpox. SN - 0098-7484 M3 - doi: 10.1001/jama.301.10.1086 UR - http://dx.doi.org/10.1001/jama.301.10.1086 ER -